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Metabolomics-based research may further reveal valuable biomarkers for therapy monitoring, as the reprogramming of ammonium metabolism in prostate cancer generates a range of intermediate metabolites, such as polyamines, citrate, and various amino acids, as well as key metabolic enzymes, which hold promise as indicators of therapeutic response (284)

The PEN form does not change any of these mechanisms

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Kidney injury was assessed using serum creatinine laboratory values

10.1016/0092-8674(94)90217-8 56 GullnerG.FodorJ.KirlyL

However, more research is still necessary